Principal Scientist, Biologics Optimization Job at Johnson & Johnson, Spring House, PA

  • Johnson & Johnson
  • Spring House, PA

Job Description

Principal Scientist position in biologics optimization at Johnson & Johnson's Spring House, PA facility. Leads integration of experimental data, engineering insights, and automation technologies to advance biologic drug discovery and establish design principles for molecule optimization.

Responsibilities

  • Lead scientific strategy for automation-enabled workflows in yeast display, NGS, and biologics optimization platforms
  • Partner with automation and therapeutic area teams to implement and improve discovery technologies across sites
  • Develop data-driven approaches to establish sequence-structure-function relationships and design principles
  • Collaborate with computational and AI/ML scientists to enhance biological understanding and discovery efficiency
  • Evaluate emerging technologies and present scientific findings to support portfolio-wide optimization decisions

Requirements

  • Master's degree in molecular biology, biochemistry, biotechnology, biomedical engineering, or structural biology
  • Expertise in biologics discovery, antibody engineering, and optimization platforms
  • Experience with yeast display, NGS, high-throughput screening, or related discovery technologies
  • Demonstrated proficiency in data-driven research and analytical approaches
  • Strong background in laboratory automation integration and workflow optimization
  • Leadership experience collaborating across cross-functional scientific teams

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